Bioinformatics in translational drug discovery
نویسندگان
چکیده
منابع مشابه
Bioinformatics and Drug Discovery
Bioinformatic analysis can not only accelerate drug target identification and drug candidate screening and refinement, but also facilitate characterization of side effects and predict drug resistance. High-throughput data such as genomic, epigenetic, genome architecture, cistromic, transcriptomic, proteomic, and ribosome profiling data have all made significant contribution to mechanismbased dr...
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SIGNIFICANCE A majority of therapeutic interventions occur late in the pathological process, when treatment outcome can be less predictable and effective, highlighting the need for new precise and preventive therapeutic development strategies that consider genomic and environmental context. Translational bioinformatics is well positioned to contribute to the many challenges inherent in bridging...
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ISSN: 2394-9759| © 2016 Bonfring Abstract--The drug discovery process was beginning in 19 century by John Langley in 1905 when he proposed the theory of respective substances. Drug discovery is the step-bystep process by which new candidate drugs are discovered. Bioinformatics deals with the exponential growth and the development in primary and secondary databases like nucleic acid sequences, p...
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Introduction ─ Bioinformatics is the part of molecular biology that involves working with biological data, typically using computers, with the goal of enabling and accelerating biological research. It is ubiquitous in drug discovery; few if any projects are computerfree. Bioinformatics spans a wide range of activities: data capture, automated recording of experimental results; data storage and ...
متن کاملUsing bioinformatics in gene and drug discovery.
Bioinformatics has, out of necessity, become a key aspect of drug discovery in the genomic revolution, contributing to both target discovery and target validation. The author describes the role that bioinformatics has played and will continue to play in response to the waves of genome-wide data sources that have become available to the industry, including expressed sequence tags, microbial geno...
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ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2017
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20160180